Comprehensive characterization of motor and coordination functions in three adolescent wild-type mouse strains.

ABSTRACT: Neuropsychiatric disorders are often associated with motor and coordination abnormalities that have important implications on the etiology, pathophysiology, and management of these disorders. Although the onset of many neuropsychiatric disorders including autism spectrum disorder, schizophrenia, and attention-deficit hyperactivity disorder emerges mainly during infancy and adolescence, most of the behavioral studies in mice modeling neuropsychiatric phenotypes are performed in adult animals, possibly missing valuable phenotypic information related to the effect of synaptic maturation during development. Here, we examined which behavioral tests assessing both motor and coordination functions can be performed in mice at two different adolescent stages. As strain and sex affect mouse behavior

SUBMITTER: Eltokhi A 

PROVIDER: S-EPMC7985312 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature