Ontology highlight
ABSTRACT:
SUBMITTER: Robertson MG
PROVIDER: S-EPMC7985464 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Robertson Matthew Glen MG Eidenschink Benjamin Bruce BB Iguchi Eriko E Zakharkin Stanislav O SO LaRocca Christopher J CJ Tolosa Ezequiel J EJ Truty Mark J MJ Jacobsen Kari K Fernandez-Zapico Martin E ME Davydova Julia J
Molecular therapy oncolytics 20210305
Encoding the sodium iodide symporter (NIS) by an adenovirus (Ad) is a promising strategy to facilitate non-invasive imaging and radiotherapy of pancreatic cancer. However, insufficient levels of NIS expression in tumor cells have limited its clinical translation. To optimize Ad-based radiotherapy and imaging, we investigated the effect of Ad death protein (ADP) deletion on NIS expression. We cloned two sets of oncolytic NIS-expressing Ads that differed only in the presence or absence of ADP. We ...[more]