Body mass index trajectories during mid to late life and risks of mortality and cardiovascular outcomes: Results from four prospective cohorts.

ABSTRACT:

Background

Our understanding of the weight-outcome association mainly comes from single-time body mass index (BMI) measurement. However, data on long-term trajectories of within-person changes in BMI on diverse study outcomes are sparse. Therefore, this study is to determine the associations of individual BMI trajectories and cardiovascular outcomes.

Methods

The present analysis was based on data from 4 large prospective cohorts and restricted to participants aged ≥45 years with at least two BMI measurements. Hazard ratios (HR) and 95% confidence intervals(95%CI) for each outcome according to different BMI trajectories were calculated in Cox regression models.

Findings

The final sample comprised 29,311 individuals (mean age 58.31 years, and 77.31% were white),

SUBMITTER: Cheng YJ 

PROVIDER: S-EPMC7985466 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature