Arylesterase activity of paraoxonase 1 (PON1) on HDL₃ and HDL₂: Relationship with Q192R, C-108T, and L55M polymorphisms.

ABSTRACT:

Background

Controversy exists regarding the role of the subfractions of high-density lipoproteins (HDL₂ and HDL₃) in cardiovascular disease. The functionality of these particles, and their protective role, is due in part to the paraoxonase 1 (PON1) presence in them. The polymorphisms rs662 (Q192R, A/G), rs854560 (L55 M, T/A), and rs705379 (C-108T) of the PON1 gene have been related to enzyme activity and, with the anti-oxidative capacity of the HDL. The objective was to determine the arylesterase PON1 activity in HDL₃ and HDL₂ and its relationship with the polymorphisms mentioned, in a young population.

Methods

The polymorphisms were determined through mini-sequencing (SnaPshot). The HDL subpopulations were separated via ionic prec

SUBMITTER: Valencia C SY 

PROVIDER: S-EPMC7985468 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature