Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders.

ABSTRACT: In patients with cardiovascular disorders, blood total ketone body (TKB) levels increase with worsening heart failure and are consumed as an alternative fuel to fatty acid and glucose. We investigated factors contributing to the increase in the blood TKB levels in patients with cardiovascular disorders. The study population consisted of 1030 consecutive patients who underwent cardiac catheterization. Covariance structure analyses were performed to clarify the direct contribution of hemodynamic parameters, including the left ventricular end-diastolic pressure (LVEDP), left ventricular end-systolic volume index (LVESVI), left ventricular end-diastolic volume index (LVEDVI), and B-type natriuretic peptide (BNP) levels, to TKB by excluding other confounding factors. These analyses showed that

SUBMITTER: Kashiwagi Y 

PROVIDER: S-EPMC7985483 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature