Anti-tumor effect of carrimycin on oral squamous cell carcinoma cells in vitro and in vivo.

ABSTRACT:

Purpose

Carrimycin is a newly synthesized macrolide antibiotic with good antibacterial effect. Exploratory experiments found its function in regulating cell physiology, proliferation and immunity, suggesting its potential anti-tumor capacity. The aim of this study is to investigate the anti-tumor effect of carrimycin against human oral squamous cell carcinoma cells in vitro and in vivo.

Methods

Human oral squamous cell carcinoma cells (HN30/HN6/Cal27/HB96 cell lines) were treated with gradient concentration of carrimycin. Cell proliferation, colony formation and migration ability were analyzed. Cell cycle and apoptosis were assessed by flow cytometry. The effect of carrimycin on OSCC in vivo was investigated in tumor xenograft models. Immunohistochemistry, western blot assay

SUBMITTER: Liang SY 

PROVIDER: S-EPMC7985557 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature