Expression of Ascaris lumbricoides putative virulence-associated genes when infecting a human host.

ABSTRACT:

Background

Ascaris lumbricoides is the most common causative agent of soil-transmitted helminth infections worldwide, with an estimated 450 million people infected with this nematode globally. It is suggested that helminths are capable of evading and manipulating the host immune system through the release of a spectrum of worm proteins which underpins their long-term survival in the host. We hypothesise that the worm overexpresses these proteins when infecting adults compared to children to cirvumvent the more robust defence mechanisms of adults. However, little is known about the parasite's genes and encoded proteins involved during A. lumbricoides infection. Hence, this study was conducted to assess the expression profile of putative virulence-associated genes during an active in

SUBMITTER: Mohd-Shaharuddin N 

PROVIDER: S-EPMC7985925 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature