Fasting status and metabolic health in relation to plasma branched chain amino acid concentrations in women.

ABSTRACT:

Background

Circulating branched chain amino acids (BCAA) are associated with cardiometabolic risk, although the mechanisms leading to their accumulation remain uncertain. Examining the relationship between fasting status, metabolic syndrome, and type 2 diabetes (T2D) with circulating BCAA levels may provide insights into their metabolic handling.

Methods

We conducted cross-sectional analyses among 25,740 Women's Health Study participants (mean age 55 years).

Results

In multivariable linear regression models, fasting was associated with lower plasma BCAAs vs. non-fasting in women without metabolic syndrome or T2D (% mean difference = -5.1%; 95% CI = -5.8, -4.5) and among women with metabolic syndrome only (-3.7%; -4.9, -2.6), p_interaction = 0.002. However, t

SUBMITTER: Tobias DK 

PROVIDER: S-EPMC7985990 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature