Tanshinone IIA regulates microRNA‑125b/foxp3/caspase‑1 signaling and inhibits cell viability of nasopharyngeal carcinoma.

ABSTRACT: Nasopharyngeal carcinoma (NPC) is a common disease with high prevalence worldwide, affecting hundreds of thousands of patients every year. Although its progress can be inhibited by concurrent chemoradiotherapy and platinum‑based agents, there is also a need for novel drugs to treat NPC. The present study identified tanshinone IIA as a potent drug that could suppress the proliferation of HK1 cells by enhancing pyroptosis via regulation of the miR‑125b/foxp3/caspase‑1 signaling pathway. Firstly, the effects of tanshinone IIA on HK1 cells were assessed and it was confirmed that treatment with tanshinone IIA significantly decreased the proliferation of HK1 cells, with increased activity of caspase‑3 and caspase‑9. Then, the pyroptosis levels after tanshinone IIA administration were detected. T

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7985994 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature