Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions.

ABSTRACT: Zinc ions play an important role in numerous crucial biological processes in the human body. The ability to image the function of Zn²⁺ would be a significant asset to biomedical research for monitoring various physiopathologies dependent on its fate. To this end, we developed a novel Gd³⁺ chelate that can selectively recognize Zn²⁺ over other abundant endogenous metal ions and alter its paramagnetic properties. More specifically, this lanthanide chelate displayed an extraordinary increase in longitudinal relaxivity (r₁ ) of over 400 % upon interaction with Zn²⁺ at 7 T and 25 °C, which is the greatest r₁ enhancement observed for any of the metal ion-responsive Gd-based complexes at high magnetic field. A "turn-on" mechanism r

SUBMITTER: Wang G 

PROVIDER: S-EPMC7986093 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature