Stem-cell-based therapies for retinal degenerative diseases: Current challenges in the establishment of new treatment strategies.

ABSTRACT: Various advances have been made in the treatment of retinal diseases, including new treatment strategies and innovations in surgical devices. However, the treatment of degenerative retinal diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), continues to pose a significant challenge. In this review, we focus on the use of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) to treat retinal diseases by harnessing the ability of stem cells to differentiate into different body tissues. The retina is a tissue specialized for light sensing, and its degradation leads to vision loss. As part of the central nervous system, the retina has very low regenerative capability, and therefore, treatment options are limited once it degenerates. Neverthe

SUBMITTER: Uyama H 

PROVIDER: S-EPMC7986097 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature