Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer.

ABSTRACT: The aim of this study was to validate prostate cancer-associated genes on transcript level and to assess the prognostic value of the most promising markers by immunohistochemistry. Based on differentially expressed genes found in a previous study, 84 genes were further validated using mRNA expression data and follow-up information from the Cancer Genome Atlas (TCGA) prostate cancer cohort (n = 497). Immunohistochemistry was used for validation of three genes in an independent, clinically annotated prostatectomy patient cohort (n = 175) with biochemical relapse as endpoint. Also, associations with clinicopathological variables were evaluated. Eleven protein-coding genes from the list of 84 genes were associated with biochemical recurrence-free survival on mRNA expression level in multivaria

SUBMITTER: Stinnesbeck M 

PROVIDER: S-EPMC7986212 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature