The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo.

ABSTRACT:

Key points

Reduced vitamin D receptor (VDR) expression prompts skeletal muscle atrophy. Atrophy occurs through catabolic processes, namely the induction of autophagy, while anabolism remains unchanged. In response to VDR-knockdown mitochondrial function and related gene-set expression is impaired. In vitro VDR knockdown induces myogenic dysregulation occurring through impaired differentiation. These results highlight the autonomous role the VDR has within skeletal muscle mass regulation.

Abstract

Vitamin D deficiency is estimated to affect ∼40% of the world's population and has been associated with impaired muscle maintenance. Vitamin D exerts its actions through the vitamin D receptor (VDR), the expression of which was recently confirmed in skeletal muscle, and its down-reg

SUBMITTER: Bass JJ 

PROVIDER: S-EPMC7986223 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature