The migratory pathways of the cells that form the endocardium, dorsal aortae, and head vasculature in the mouse embryo.

ABSTRACT:

Background

Vasculogenesis in amniotes is often viewed as two spatially and temporally distinct processes, occurring in the yolk sac and in the embryo. However, the spatial origins of the cells that form the primary intra-embryonic vasculature remain uncertain. In particular, do they obtain their haemato-endothelial cell fate in situ, or do they migrate from elsewhere? Recently developed imaging techniques, together with new Tal1 and existing Flk1 reporter mouse lines, have allowed us to investigate this question directly, by visualising cell trajectories live and in three dimensions.

Results

We describe the pathways that cells follow to form the primary embryonic circulatory system in the mouse embryo. In particular, we show that Tal1-positive cells migrate from within the y

SUBMITTER: Collart C 

PROVIDER: S-EPMC7986287 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature