A non-invasive nanoparticles for multimodal imaging of ischemic myocardium in rats.

ABSTRACT:

Background

Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide, and imposes a serious economic load. Thus, it is crucial to perform a timely and accurate diagnosis and monitoring in the early stage of myocardial ischemia. Currently, nanoparticles (NPs) have emerged as promising tools for multimodal imaging, because of their advantages of non-invasion, high-safety, and real-time dynamic imaging, providing valuable information for the diagnosis of heart diseases.

Results

In this study, we prepared a targeted nanoprobe (termed IMTP-Fe₃O₄-PFH NPs) with enhanced ultrasound (US), photoacoustic (PA), and magnetic resonance (MR) performance for direct and non-invasive visual imaging of ischemic myocardium in a rat model. This

SUBMITTER: Chen X 

PROVIDER: S-EPMC7986298 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature