Severity of COVID-19 infection in ACEI/ARB users in specialty hospitals: A retrospective cohort study.

ABSTRACT:

Background

The uncertainty about COVID-19 outcomes in angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) users continues with contradictory findings. This study aimed to determine the effect of ACEI/ARB use in patients with severe COVID-19.

Methods

This retrospective cohort study was done in two Saudi public specialty hospitals designated as COVID-19 referral facilities. We included 354 patients with a confirmed diagnosis of COVID-19 between April and June 2020, of which 146 were ACEI/ARB users and 208 were non-ACEI/ARB users. Controlling for confounders, we conducted multivariate logistic regression and sensitivity analyses using propensity score matching (PSM) and Inverse propensity score weighting (IPSW) for high-risk patient subsets.

R

SUBMITTER: Alrashed AA 

PROVIDER: S-EPMC7986317 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature