Mechanochemical Solvent-Free Catalytic C-H Methylation.

ABSTRACT: The mechanochemical, solvent-free, highly regioselective, rhodium-catalyzed C-H methylation of (hetero)arenes is reported. The reaction shows excellent functional-group compatibility and is demonstrated to work for the late-stage C-H methylation of biologically active compounds. The method requires no external heating and benefits from considerably shorter reaction times than previous solution-based C-H methylation protocols. Additionally, the mechanochemical approach is shown to enable the efficient synthesis of organometallic complexes that are difficult to generate conventionally.

SUBMITTER: Ni S 

PROVIDER: S-EPMC7986365 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature