Oxidative stress links periodontal inflammation and renal function.

ABSTRACT:

Aims

Patients with chronic kidney disease (CKD) are also susceptible to periodontitis. The causal link between periodontitis and CKD may be mediated via systemic inflammation/oxidative stress. Using structural equation modelling (SEM), this cross-sectional study aimed to explore the causal relationship between periodontal inflammation (PI) and renal function.

Materials and methods

Baseline data on 770 patients with stage 3-5 (pre-dialysis) CKD from an ongoing cohort study were used. Detailed, bioclinical data on PI and renal function, as well as potential confounders and mediators of the relationship between the two, were collected. SEMs of increasing complexity were created to test the causal assumption that PI affects renal function and vice versa.

Results

Structura

SUBMITTER: Sharma P 

PROVIDER: S-EPMC7986430 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature