20-year longitudinal follow-up of measured and estimated glomerular filtration rate in kidney transplant patients.

ABSTRACT:

Background

The slopes of estimated glomerular filtration rate (eGFR) equations are used in the longitudinal follow-up of transplant patients. A 30% reduction in eGFR over 2 years is often used to predict the subsequent risk of mortality or end-stage renal disease. Whether, at the individual level, such changes in eGFR correspond to changes in measured GFR (mGFR) is actually unknown.

Methods

The performance of serum creatinine-based eGFR equations was compared with mGFR during the longitudinal follow-up of 20 years in a monocentric study of 417 transplanted patients.

Results

The accuracy within 30% for the eGFR equations varied between 70 and 75%. All eGFR equations showed a similar pattern, very like the mGFR time profiles. Individual changes (slopes) of mGFR or eGFR

SUBMITTER: Pottel H 

PROVIDER: S-EPMC7986444 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature