Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology.

ABSTRACT: Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer's disease (AD), wide variation in cognitive trajectories during life can be seen in the setting of brain amyloidosis, ranging from maintenance of normal function to progression to dementia. It is widely presumed that cognitive resilience (i.e., coping) to amyloidosis may be influenced by environmental, lifestyle, and inherited factors, but relatively little in specifics is known about this architecture. Here, we leveraged multimodal longitudinal data from a large, population-based sample of older adults to discover genetic factors associated with differential cognitive resilience to brain amyloidosis determined by positron emission tomography (PET). Among amyloid-PET positive older adults, the AD risk

SUBMITTER: Ramanan VK 

PROVIDER: S-EPMC7986461 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature