Ontology highlight
ABSTRACT:
SUBMITTER: Meyer CT
PROVIDER: S-EPMC7986484 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Meyer Christian T CT Wooten David J DJ Lopez Carlos F CF Quaranta Vito V
Trends in pharmacological sciences 20200226 4
Even as the clinical impact of drug combinations continues to accelerate, no consensus on how to quantify drug synergy has emerged. Rather, surveying the landscape of drug synergy reveals the persistence of historical fissures regarding the appropriate domains of conflicting synergy models - fissures impacting all aspects of combination therapy discovery and deployment. Herein we chronicle the impact of these divisions on: (i) the design, interpretation, and reproducibility of high-throughput co ...[more]