Incidence of antidepressant use among community dwellers with and without Parkinson's disease - a nationwide cohort study.

ABSTRACT:

Background

Antidepressant use is more common in people with Parkinson's disease (PD), but it is unknown when this difference emerges.

Methods

We studied the incidence of antidepressant use in six-month periods from 10 years before to 15 years after PD diagnosis in the nationwide register-based Finnish Study on Parkinson's disease (FINPARK). This study included 20,456 community dwellers with clinically verified PD diagnosed during 1996-2015 and 140,291 matched comparison persons.

Results

Altogether 44.3% of people with PD initiated antidepressants, compared to 25.0% of people without PD. The difference was largest 6 months before PD diagnosis (incidence rate ratio 5.28, 95% CI 4.80-5.80; 9.02 and 1.68 initiations/100 person-years in people with and without PD, respecti

SUBMITTER: Hentila E 

PROVIDER: S-EPMC7986562 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature