A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ.

ABSTRACT:

Key points

Mouse chromaffin cells in acute adrenal slices exhibit two distinct spiking patterns, a repetitive mode and a bursting mode. A sodium background conductance operates at rest as demonstrated by the membrane hyperpolarization evoked by a low Na⁺ -containing extracellular saline. This sodium background current is insensitive to TTX, is not blocked by Cs⁺ ions and displays a linear I-V relationship at potentials close to chromaffin cell resting potential. Its properties are reminiscent of those of the sodium leak channel NALCN. In the adrenal gland, Nalcn mRNA is selectively expressed in chromaffin cells. The study fosters our understanding of how the spiking pattern of chromaffin cells is regulated and adds a sodium background conductance to the list o

SUBMITTER: Milman A 

PROVIDER: S-EPMC7986707 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature