Criteria for low von Willebrand factor diagnosis and risk score to predict future bleeding.

ABSTRACT:

Background

Important diagnostic and clinical aspects of moderately reduced von Willebrand factor (VWF) levels are still unknown. There is no clear evidence which cutoff value (0.50 vs 0.60 IU/ml) should be used to diagnose "low VWF." Also, the incidence of bleeding after the diagnosis has been made, and risk factors for bleeding are unknown yet.

Objectives

To investigate the incidence of postsurgical bleeding, postpartum hemorrhage (PPH), and traumatic and spontaneous bleeding after low VWF diagnosis, and to develop a risk score to predict future bleeding.

Methods

We performed a cohort study in patients with historically lowest VWF levels of 0.31 to 0.60 IU/ml. Clinical data of patients were retrospectively collected.

Results

We included 439 patients with low V

SUBMITTER: Atiq F 

PROVIDER: S-EPMC7986755 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature