Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing.

ABSTRACT:

Background

Photoageing describes complex cutaneous changes which occur following chronic exposure to solar ultraviolet radiation (UVR). Amongst White Northern Europeans, facial photoageing appears as distinct clinical phenotypes: 'hypertrophic' photoageing (HP) and 'atrophic' photoageing (AP). Deep, coarse wrinkles predominate in individuals with HP, whereas those with AP have relatively smooth, unwrinkled skin with pronounced telangiectasia. AP individuals have an increased propensity for developing keratinocyte cancers.

Objectives

To investigate whether histological differences underlie these distinct phenotypes of facial photoageing.

Methods

Facial skin biopsies were obtained from participants with AP (10 M, 10 F; mean age: 78.7 years) or HP (10 M, 10 F; mean age:

SUBMITTER: Langton AK 

PROVIDER: S-EPMC7986784 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature