Progesterone for prevention of preterm birth in women with short cervical length: 2-year infant outcomes.

ABSTRACT:

Objective

To evaluate the long-term outcomes of children born to women with a short cervix and otherwise low risk for preterm birth, after antenatal exposure to vaginal progesterone vs placebo.

Methods

This was a follow-up study of the Triple P trial, which randomized 80 low-risk women with a short cervix (≤ 30 mm) at 18-22 weeks' gestation to progesterone (n = 41) or placebo (n = 39). At 2 years of corrected age, children were invited for a neurodevelopmental assessment, using the Bayley Scales of Infant and Toddler Development, third edition (BSID-III), and a neurological and physical examination by an assessor blinded to the allocated treatment. Parents filled out the Ages and Stages Questionnaire, the Child Behavior Checklist (CBCL) and a general-health questionnaire. Th

SUBMITTER: Cuijpers CJJ 

PROVIDER: S-EPMC7986902 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature