PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin.

ABSTRACT: A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity.

SUBMITTER: de Waard AA 

PROVIDER: S-EPMC7986913 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature