Ontology highlight
ABSTRACT:
SUBMITTER: Khan S
PROVIDER: S-EPMC7987013 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Khan Shahanshah S Shafiei Mahnoush S MS Longoria Christopher C Schoggins John J Savani Rashmin C RC Zaki Hasan H
bioRxiv : the preprint server for biology 20210317
Pathogenesis of COVID-19 is associated with a hyperinflammatory response; however, the precise mechanism of SARS-CoV-2-induced inflammation is poorly understood. Here we investigated direct inflammatory functions of major structural proteins of SARS-CoV-2. We observed that spike (S) protein potently induces inflammatory cytokines and chemokines including IL-6, IL-1ß, TNFa, CXCL1, CXCL2, and CCL2, but not IFNs in human and mouse macrophages. No such inflammatory response was observed in response ...[more]