Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.

ABSTRACT:

Background

There is considerable variability in COVID-19 outcomes amongst younger adults-and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium.

Method

The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by

SUBMITTER: Nakanishi T 

PROVIDER: S-EPMC7987046 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature