Engineering antibody-based molecules for HIV treatment and cure.

ABSTRACT:

Purpose of review

Immunotherapy strategies alternative to current antiretroviral therapies will need to address viral diversity while increasing the immune system's ability to efficiently target the latent virus reservoir. Antibody-based molecules can be designed based on broadly neutralizing and non-neutralizing antibodies that target free virions and infected cells. These multispecific molecules, either by IgG-like or non-IgG-like in structure, aim to target several independent HIV-1 epitopes and/or engage effector cells to eliminate the replicating virus and infected cells. This detailed review is intended to stimulate discussion on future requirements for novel immunotherapeutic molecules.

Recent findings

Bispecific and trispecific antibodies are engineered as a single m

SUBMITTER: Tuyishime M 

PROVIDER: S-EPMC7987066 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature