Repetitive in vivo manual loading of the spine elicits cellular responses in porcine annuli fibrosi.

ABSTRACT: Back pain and intervertebral disc degeneration are prevalent, costly, and widely treated by manual therapies, yet the underlying causes of these diseases are indeterminate as are the scientific bases for such treatments. The present studies characterize the effects of repetitive in vivo manual loads on porcine intervertebral disc cell metabolism using RNA deep sequencing. A single session of repetitive manual loading applied to the lumbar spine induced both up- and down-regulation of a variety of genes transcribed by cells in the ventral annuli fibrosi. The effect of manual therapy at the level of loading was greater than at a level distant to the applied load. Gene ontology and molecular pathway analyses categorized biological, molecular, and cellular functions influenced by repetitive ma

SUBMITTER: Matyas JR 

PROVIDER: S-EPMC7987143 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature