Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior.

ABSTRACT: Voltage-gated potassium (Kv) channels regulate the membrane potential and conductance of excitable cells to control the firing rate and waveform of action potentials. Even though Kv channels have been intensely studied for over 70 year, surprisingly little is known about how specific channels expressed in various neurons and their functional properties impact neuronal network activity and behavior in vivo. Although many in vivo genetic manipulations of ion channels have been tried, interpretation of these results is complicated by powerful homeostatic plasticity mechanisms that act to maintain function following perturbations in excitability. To better understand how Kv channels shape network function and behavior, we have developed a novel optogenetic technology to acutely regulate Kv cha

SUBMITTER: Jerng HH 

PROVIDER: S-EPMC7987177 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature