Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.

ABSTRACT:

Background

Studies have found different waning rates of neutralising antibodies compared with binding antibodies against SARS-CoV-2. The impact of neutralising antibody waning rate at the individual patient level on the longevity of immunity remains unknown. We aimed to investigate the peak levels and dynamics of neutralising antibody waning and IgG avidity maturation over time, and correlate this with clinical parameters, cytokines, and T-cell responses.

Methods

We did a longitudinal study of patients who had recovered from COVID-19 up to day 180 post-symptom onset by monitoring changes in neutralising antibody levels using a previously validated surrogate virus neutralisation test. Changes in antibody avidities and other immune markers at different convalescent stages were

SUBMITTER: Chia WN 

PROVIDER: S-EPMC7987301 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature