MicroRNA-552 expression in colorectal cancer and its clinicopathological significance.

ABSTRACT:

Background

MicroRNA-552 (miR-552) has been reported to correlate with the development and progression of various cancers, including colorectal cancer (CRC). This study aimed to investigate miR-552 expression in cancer tissue samples compared to normal mucosal tissue and its role as a diagnostic or prognostic marker in CRC patients.

Methods

Normal mucosal tissues and primary cancer tissues from 80 surgically resected CRC specimens were used. Quantitative real-time polymerase chain reaction was performed for miR-552 and U6 small nuclear RNA to analyze miR-552 expression and its clinicopathological significance. Immunohistochemistry for p53 and phosphatase and tension homolog (PTEN) was performed to evaluate their association with miR-552 expression.

Results

miR-552 expr

SUBMITTER: Im J 

PROVIDER: S-EPMC7987523 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature