Human Histone Interaction Networks: An Old Concept, New Trends.

ABSTRACT: To elucidate the properties of human histone interactions on the large scale, we perform a comprehensive mapping of human histone interaction networks by using data from structural, chemical cross-linking and various high-throughput studies. Histone interactomes derived from different data sources show limited overlap and complement each other. It inspires us to integrate these data into the combined histone global interaction network which includes 5308 proteins and 10,330 interactions. The analysis of topological properties of the human histone interactome reveals its scale free behavior and high modularity. Our study of histone binding interfaces uncovers a remarkably high number of residues involved in interactions between histones and non-histone proteins, 80-90% of residues in histon

SUBMITTER: Peng Y 

PROVIDER: S-EPMC7987645 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature