Association of Midlife Cardiovascular Risk Factors With the Risk of Heart Failure Subtypes Later in Life.

ABSTRACT:

Background

Independent associations between cardiovascular risk factor exposures during midlife and later life development of heart failure (HF) with preserved ejection fraction (HFpEF) versus reduced EF (HFrEF) have not been previously studied.

Methods

We pooled data from 4 US cohort studies (Atherosclerosis Risk in Communities, Cardiovascular Health, Health , Aging and Body Composition, and Multi-Ethnic Study of Atherosclerosis) and imputed annual risk factor trajectories for body mass index, systolic and diastolic blood pressure, low-density lipoprotein and high-density lipoprotein cholesterol, and glucose starting from age 40 years. Time-weighted average exposures to each risk factor during midlife and later life were calculated and analyzed for associations with the dev

SUBMITTER: Cohen LP 

PROVIDER: S-EPMC7987686 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature