Analysis of DNA variants in miRNAs and miRNA 3'UTR binding sites in female infertility patients.

ABSTRACT: Early human embryogenesis relies on maternal gene products accumulated during oocyte growth and maturation, until around day-3 post-fertilization when human zygotic genome activation occurs. The maternal-to-zygotic transition (MZT) is a tightly coordinated process of selective maternal transcript clearance and new zygotic transcript production. If MZT is disrupted, it will lead to developmental arrest and pregnancy loss. It is well established that microRNA (miRNA) mutations disrupt regulation of their target transcripts. We hypothesize that some cases of embryonic arrest and pregnancy loss could be explained by the mutations in the maternal genome that affect miRNA-target transcript pairs. To this end, we examined mutations within miRNAs or miRNA binding sites in the 3' untranslated regio

SUBMITTER: Tyc KM 

PROVIDER: S-EPMC7987713 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature