Nutrition, one-carbon metabolism and arsenic methylation in Bangladeshi adolescents.

ABSTRACT:

Background

Over 57 million people in Bangladesh are chronically exposed to arsenic-contaminated drinking water. Ingested inorganic arsenic (InAs) undergoes hepatic methylation generating monomethyl- (MMAs) and dimethyl- (DMAs) arsenic species in a process that facilitates urinary As (uAs) elimination. One-carbon metabolism (OCM), a biochemical pathway that is influenced by folate and vitamin B12, facilitates the methylation of As. OCM also supports nucleotide and amino acid synthesis, particularly during periods of rapid growth such as adolescence. While folate supplementation increases As methylation and lowers blood As (bAs) in adults, little data is available for adolescents.

Objectives

To examine the associations between OCM-related micronutrients and As methylation in B

SUBMITTER: Saxena R 

PROVIDER: S-EPMC7987757 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature