Resting-State Functional Connectivity Predicts STN DBS Clinical Response.

ABSTRACT:

Background

Deep brain stimulation of the subthalamic nucleus is a widely used adjunctive therapy for motor symptoms of Parkinson's disease, but with variable motor response. Predicting motor response remains difficult, and novel approaches may improve surgical outcomes as well as the understanding of pathophysiological mechanisms. The objective of this study was to determine whether preoperative resting-state functional connectivity MRI predicts motor response from deep brain stimulation of the subthalamic nucleus.

Methods

We collected preoperative resting-state functional MRI from 70 participants undergoing subthalamic nucleus deep brain stimulation. For this cohort, we analyzed the strength of STN functional connectivity with seeds determined by stimulation-induced (ON/OFF

SUBMITTER: Younce JR 

PROVIDER: S-EPMC7987812 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature