Osr1 regulates hepatic inflammation and cell survival in the progression of non-alcoholic fatty liver disease.

ABSTRACT: Odd-skipped related 1 (Osr1) is a novel tumor suppressor gene in several cancer cell lines. Non-alcoholic steatohepatitis (NASH) is considered as a high-risk factor for hepatocellular carcinoma (HCC). This study is aimed to investigate the novel role of Osr1 in promoting the progression of hepatic steatosis to NASH. Following 12 weeks of diethylnitrosamine (DEN) and high-fat diet (HFD), wildtype (WT) and Osr1 heterozygous (Osr1^+/-) male mice were examined for liver injuries. Osr1^+/- mice displayed worsen liver injury with higher serum alanine aminotransferase levels than the WT mice. The Osr1^+/- mice also revealed early signs of collagen deposition with increased hepatic Tgfb and Fn1 expression. There was overactivation of both JNK and NF-κB signaling in th

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7987871 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature