Comparison of neuropathology in rats following status epilepticus induced by diisopropylfluorophosphate and soman.

ABSTRACT: The increasing number of cases involving the use of nerve agents as deadly weapons has spurred investigation into the molecular mechanisms underlying nerve agent-induced pathology. The highly toxic nature of nerve agents restrict their use in academic research laboratories. Less toxic organophosphorus (OP) based agents including diisopropylfluorophosphate (DFP) are used as surrogates in academic research laboratories to mimic nerve agent poisoning. However, neuropathology resulting from DFP-induced status epilepticus (SE) has not been compared directly to neuropathology observed following nerve agent poisoning in the same study. Here, the hypothesis that neuropathology measured four days after SE is the same for rats exposed to DFP and soman was tested. Adult Sprague-Dawley rats were injec

SUBMITTER: Rojas A 

PROVIDER: S-EPMC7987879 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature