Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma.

ABSTRACT: Dysregulated amino acids metabolism reciprocally interplays with evolutionary phenotypic characteristics of cancer cells to enhance metastasis. The high metastasis potential of oral squamous cell carcinoma (OSCC) can manifest with perineural invasion (PNI). We here aimed to determine the role of amino acids metabolism in OSCCs with different PNI statuses. Targeted metabolomics was used to quantify 48 amino acids in 20 fresh OSCC samples and 25 amino acids were successfully detected, within which 9 were significantly up-regulated in PNI positive (PNI⁺) samples. As its highest area under the curve value (0.9063), l-asparagine was selected as the biomarker to distinguish PNI⁺ from PNI negative (PNI^-). Then, the key enzyme of l-asparagine, asparagine synthetase

SUBMITTER: Fu Y 

PROVIDER: S-EPMC7987891 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature