Volumetric Brain Changes in Older Fallers: A Voxel-Based Morphometric Study.

ABSTRACT:

Background

Falls are frequent and severe in older adults, especially among those with cognitive impairments due to altered motor control. Which brain areas are affected among fallers remains yet not elucidated. The objective of this cross-sectional analysis was to determine whether the history of falls correlated with focal brain volume reductions in older adults.

Methods

Participants from the MERE study (n = 208; mean, 71.9 ± 5.9 years; 43% female; 38% cognitively healthy, 41% with mild cognitive impairment and 21% with dementia) were asked about their history of falls over the preceding year and received a 1.5-Tesla MRI scan of the brain. Cortical gray and white matter subvolumes were automatically segmented using Statistical Parametric Mapping. Age, gender, use of

SUBMITTER: Le Floch M 

PROVIDER: S-EPMC7987921 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature