Randomized Double-Blind Controlled Trial Comparing 0.2 mg, 0.1 mg, and No Intrathecal Morphine Combined With Periarticular Injection for Unilateral Total Knee Arthroplasty.

ABSTRACT:

Background

The addition of intrathecal morphine (ITM) to neuraxial anesthesia during total knee arthroplasty (TKA) to achieve postoperative analgesia can elicit opioid-related side effects. The other methods of pain alleviation and side effect reduction, including multimodal analgesia, are challenging. This study aimed to determine the efficacy of various ITM dosages for primary unilateral TKA with periarticular injection (PI).

Methods

This randomized double-blind controlled trial was conducted at Vajira Hospital between April 2018 and March 2019. Patients undergoing TKA were randomized into 3 groups: no ITM (M₀), ITM 0.1 mg (M₁), and ITM 0.2 mg (M₂). All patients received PI. Postoperative pain scores, side effects of ITM, and orthopedic out

SUBMITTER: Pathonsamit C 

PROVIDER: S-EPMC7987934 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature