Ontology highlight
ABSTRACT:
SUBMITTER: Rossi JJ
PROVIDER: S-EPMC7987981 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Rossi Joseph J JJ Rosenfeld Jill A JA Chan Katie M KM Streff Haley H Nankivell Victoria V Peet Daniel J DJ Whitelaw Murray L ML Bersten David C DC
Scientific reports 20210323 1
Aberrations in the excitatory/inhibitory balance within the brain have been associated with both intellectual disability (ID) and schizophrenia (SZ). The bHLH-PAS transcription factors NPAS3 and NPAS4 have been implicated in controlling the excitatory/inhibitory balance, and targeted disruption of either gene in mice results in a phenotype resembling ID and SZ. However, there are few human variants in NPAS3 and none in NPAS4 that have been associated with schizophrenia or neurodevelopmental diso ...[more]