Erianthridin suppresses non-small-cell lung cancer cell metastasis through inhibition of Akt/mTOR/p70^S6K signaling pathway.

ABSTRACT: Cancer metastasis is a major cause of the high mortality rate in lung cancer patients. The cytoskeletal rearrangement and degradation of extracellular matrix are required to facilitate cell migration and invasion and the suppression of these behaviors is an intriguing approach to minimize cancer metastasis. Even though Erianthridin (ETD), a phenolic compound isolated from the Thai orchid Dendrobium formosum exhibits various biological activities, the molecular mechanism of ETD for anti-cancer activity is unclear. In this study, we found that noncytotoxic concentrations of ETD (≤ 50 μM) were able to significantly inhibit cell migration and invasion via disruption of actin stress fibers and lamellipodia formation. The expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 was markedly do

SUBMITTER: Pothongsrisit S 

PROVIDER: S-EPMC7987990 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature