Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain.

ABSTRACT: Osteoarthritis (OA) pain is associated with peripheral and central sensitization in humans and results in widespread increased sensitivity across the body. Sensitization contributes to the OA-associated pain (OAP) state. We recently identified increased levels of an endogenous neurotrophic factor, artemin (ARTN), in dogs with OAP compared to healthy pain-free controls. Circulating ARTN released from damaged tissues in OA, may play a central role in widespread sensitivity and pain. However, the relationship between ARTN and somatosensory sensitivity remains unknown. The study aimed to assess the relationship between serum ARTN concentrations and measures of sensitivity in dogs with OAP using quantitative sensory testing. We hypothesized that there would be a positive association between cir

SUBMITTER: Gupta A 

PROVIDER: S-EPMC7988108 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature