Bidirectional and state-dependent modulation of brain activity by transcranial focused ultrasound in non-human primates.

ABSTRACT: Transcranial focused ultrasound (FUS) stimulation under MRI guidance, coupled with functional MRI (fMRI) monitoring of effects, offers a precise, noninvasive technology to dissect functional brain circuits and to modulate altered brain functional networks in neurological and psychiatric disorders. Here we show that ultrasound at moderate intensities modulated neural activity bi-directionally. Concurrent sonication of somatosensory areas 3a/3b with 250 kHz FUS suppressed the fMRI signals produced there by peripheral tactile stimulation, while at the same time eliciting fMRI activation at inter-connected, off-target brain regions. Direct FUS stimulation of the cortex resulted in different degrees of BOLD signal changes across all five off-target regions, indicating that its modulatory effect

SUBMITTER: Yang PF 

PROVIDER: S-EPMC7988301 | biostudies-literature | 2021 Mar-Apr

REPOSITORIES: biostudies-literature