High-Dose vs Standard-Dose Amoxicillin Plus Clavulanate for Adults With Acute Sinusitis: A Randomized Clinical Trial.

ABSTRACT:

Importance

Acute bacterial sinusitis is common, but currently recommended antibiotic treatment provides minimal benefit.

Objective

To confirm the previous finding that high-dose amoxicillin plus clavulanate (with double the amount of amoxicillin) may be superior to standard-dose amoxicillin plus clavulanate in adults.

Design, setting, and participants

This double-blind, comparative-effectiveness randomized clinical trial was conducted from February 26, 2018, through May 10, 2020, at the academic primary care internal medicine and pediatrics practice of Albany Medical Center, located in Cohoes, New York. Participants included adults aged 18 years or older who were prescribed amoxicillin plus clavulanate for acute bacterial sinusitis diagnosed in accordance with the Inf

SUBMITTER: Gregory J 

PROVIDER: S-EPMC7988367 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature