C1 Silencing Attenuates Inflammation and Alveolar Bone Resorption in Endodontic Disease.

ABSTRACT:

Introduction

Endodontic disease, 1 of the most prevalent chronic infectious diseases worldwide, occurs when the dental pulp becomes infected and inflamed, leading to bone destruction around the tooth root, severe pain, and tooth loss. Although many studies have tried to develop therapies to alleviate the bone erosion and inflammation associated with endodontic disease, there is an urgent need for an effective treatment.

Methods

In this study, we used a gene-based therapy approach by administering recombinant adeno-associated virus (AAV)-mediated Atp6v1c1 knockdown to target both periapical bone resorption and inflammation in the mouse model of endodontic disease.

Results

The results showed that Atp6v1c1 knockdown is simultaneously capable of reducing bone resorption b

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7988436 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature